Adaptation to spindle assembly checkpoint inhibition through the Biology Diagrams

Adaptation to spindle assembly checkpoint inhibition through the Biology Diagrams The spindle assembly checkpoint (SAC, also known as mitotic or metaphase checkpoint) is a feedback-control system that operates during cell division in eukaryotic cells The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis. J. Biol. Chem. 2015; 290:2431-2443. Crossref. PubMed.

They provide a landing platform for the spindle-assembly checkpoint (SAC) proteins 56. The Ndc80/HEC1 complex seems to be directly involved in microtubule binding 80 , 81 .

Spindle assembly checkpoint: the third decade Biology Diagrams

The spindle assembly checkpoint controls cell cycle progression during mitosis, synchronizing it with the attachment of chromosomes to spindle microtubules. PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores. J. Cell Biol. 179, 601-609 10.1083/jcb.200703133 (doi:10.1083/jcb

Howell, B. J. et al. Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation. J. Cell Biol. 155 , 1159 Several spindle assembly checkpoint proteins act both as positive and negative regulators to ensure the proper chromosome segregation in each cell cycle preventing chromosome instability (CIN) also known as genome instability. Cytometric analysis of malignant carcinoma displaying aneuploidy.

assembly checkpoint in space and time Biology Diagrams

a, Domain organization of key spindle assembly checkpoint (SAC) proteins, where proteins and protein domains are depicted to scale.Binding partners of key domains are indicated and amino acids